Uche agreed to join Crystal Palace with a one-year loan contract and will play in the No. 12 jersey.
The 22-year-old, who has represented the Nigerian national team in high-level international competitions, performed well during his one-year period at Getafe.
After joining Getafe in the 2024/25 season, Uche made 38 appearances in various competitions, scored 4 goals and contributed 7 assists.
Chairman Steve Parrish said: "I am very happy to welcome Uche to the club, an exciting young talent and a comprehensive international player who has demonstrated his abilities during his time in Spain and everyone in the club is looking forward to seeing him thrive in South London."
Uche said: "This moment is incredible. I am very lucky to be here, and this club is a huge opportunity for me."